HOW this Algorithm works:
- Takes information about two metabolic states of the cell
- Predicts the environmental or genetic changes required to go from one state to the other
TO FIND which genes can be turned off to make the cells 'express young'
Stemcells21 |
AFTAU: "Tel Aviv University researchers have developed a computer algorithm that predicts which genes can be “turned off” to create the same anti-aging effect as calorie restriction. (Limiting calorie consumption is one of the ways to combat aging)
The findings, reported in Nature Communications, could lead to the development of new drugs to treat aging."
"Our algorithm is the first in our field to look for drug targets not to kill cells, but to transform them from a diseased state into a healthy one." -Keren Yizhak, Doctoral Student
Yizhak applied MTA to the genetics of aging. [Yizhak uses her custom-designed MTA] to predict genes that can be turned off to make the gene expression of old yeast look like that of young yeast."The Tech: Digital Laboratory
Using mathematical equations and computers, Genome-Scale Metabolic Modeling (GSMMs) can describes processes of living cells--metabolism.
"Once built, the individual models serve as digital laboratories, allowing formerly labor-intensive tests to be conducted with the click of a mouse." (AFTAU)
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